Cocaine: a receptor in the brain shuts down the dependency

   The brain is a great machine that governs our body, we know well, and as such there are present some sort of "switches".
In this regard, a study conducted by researchers National Institute on Drug Abuse, led by Zheng-Xiong Xi online and published in the journal "Nature", showed that you can turn on a "switch" to curb cocaine cravings.
In our brain are two receptors present who play a key role in meccainismi of cocaine dependence: CB1 and CB2.
   With appropriate medications you can activate the CB1cannabinoid receptor, which stimulates the cerebral mechanism tied to a sense of pleasure and reward. In the case of drugs, then, this favors the fallout after a prolonged abstinence.
The opposite effect, stimulating instead, you get another cannabinoid receptor in the brain CB2, whose role was as yet unclear. Stimulating CB2 receptor in the brain, in fact, reduce the effects and the desire to cocaine, which alter their behavior by stopping try obsessively the substance.
Therefore, researchers have identified two classes of molecules capable of turning, and then selectively enable, only CB2receptors, so that parties can greatly reduce their desire for drugs.
The study in question, which represents a real breakthrough in this area, has only been tested on mice and the results were as expected.
The studies will surely ahead, but the researchers wanted to emphasize how CB2 switch could become a target by hitting it with new therapies to mitigate the dependency and substance abuse.


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